The affordability crisis is over, Donald Trump told the US on Tuesday. The president’s state of the union address put the blame for soaring prices squarely on the “dirty, rotten” lies of the Democrats and claimed prices were now “plummeting downward”.
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The drug, called orforglipron and manufactured by Eli Lilly, is prescribed for type 2 diabetes and targets the same GLP-1 receptors as oral semaglutide. Like semaglutide, it lowers blood sugar levels, slows digestion and suppresses appetite. Unlike semaglutide tablets, it does not need to be taken on an empty stomach.
Nature, Published online: 26 February 2026; doi:10.1038/d41586-026-00622-9
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